Matching protein / nucleotide services to alignments in Jalview

Mungo - do you feel the need to patch 2.11.1 to fix up its behaviour ?

(ps - cced jalview-dev…).

In Slivka each service has classifiers which helps to identify services and and can be used to determine input and output types:
e.g JRonn, Globblot are tagged “Protein sequence analysis”, msa e.g. Clustal, t_coffee are tagged “Sequence alignment :: Multiple sequence alignment”, aacon has “Sequence alignment analysis :: Sequence alignment analysis (conservation)” tag.


From: James Procter (Staff) J.Procter@dundee.ac.uk
Sent: 14 November 2019 13:21
To: Mungo Carstairs (Staff) g.m.carstairs@dundee.ac.uk; Mateusz Warowny (Student) m.m.warowny@dundee.ac.uk
Subject: Re: Matching protein / nucleotide services to alignments in Jalview

Actually covered by JAL-1172 - but is being addressed in the Slivka revamp of Jalview’s services in 2.12.

https://issues.jalview.org/browse/JAL-1172

j.

Is there, or could there be, a way to identify services (e.g. JRonn, GlobPlot etc) that are for protein alignments only, so that they could be disabled or hidden as menu options in Jalview (or other client) for a DNA or RNA alignment (and vice versa)?

Older versions of Jalview show a warning after requesting the service, e.g. “JRonnWS can only be used for amino acid alignments.”.
This warning was suppressed (2013 by Dan Barton) when RNAAlifold prediction was added (JAL-1358).

Jalview behaviour in 2.11 is mixed (up):

  • you can request disorder prediction for nucleotide but nothing happens, no error message appears
  • AbstractJabaCalcWorker.getInputSequences() returns null if nucleotide alignment but peptide service- you can request and get a JPred peptide secondary structure prediction for a nucleotide alignment
  • AACon service is disabled for nucleotide alignments
  • RNAAlifold is disabled for protein alignments
  • you can request a Multi-Harmony analysis for a partitioned nucleotide alignment (but it fails)

Mungo

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Mungo Carstairs
Jalview Computational Scientist

The Barton Group
Division of Computational Biology

School of Life Sciences

University of Dundee, Dundee, Scotland, UK

www.jalview.org

www.compbio.dundee.ac.uk
g.m.carstairs@dundee.ac.uk

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-- 
-------------------------------------------------------------------
Dr JB Procter, Jalview Coordinator, The Barton Group
Division of Computational Biology, School of Life Sciences
University of Dundee, Dundee DD1 5EH, UK.
+44 1382 388734 | [www.jalview.org](http://www.jalview.org) | [www.compbio.dundee.ac.uk](http://www.compbio.dundee.ac.uk)

The University of Dundee is a registered Scottish Charity, No: SC015096

···

On 14/11/2019 13:24, Mateusz Warowny (Staff) wrote:

-- 
-------------------------------------------------------------------
Dr JB Procter, Jalview Coordinator, The Barton Group
Division of Computational Biology, School of Life Sciences
University of Dundee, Dundee DD1 5EH, UK.
+44 1382 388734 | [www.jalview.org](http://www.jalview.org) | [www.compbio.dundee.ac.uk](http://www.compbio.dundee.ac.uk)

No I don’t - if we’ve lived with it this long, it can wait a tiny bit longer for fixing with Slivka services!

Mungo

···

Email signature

University of Dundee shield logo

Mungo Carstairs
Jalview Computational Scientist

The Barton Group
Division of Computational Biology

School of Life Sciences

University of Dundee, Dundee, Scotland, UK

www.jalview.org

www.compbio.dundee.ac.uk
g.m.carstairs@dundee.ac.uk

University of Dundee FacebookUniversity of Dundee TwitterUniversity of Dundee LinkedInUniversity of Dundee YouTubeUniversity of Dundee InstagramUniversity of Dundee Snapchat
We’re Scottish University of the Year again!
The Times / Sunday Times Good University Guide 2016 and 2017


From: James Procter (Staff) J.Procter@dundee.ac.uk
Sent: 14 November 2019 13:26
To: Mateusz Warowny (Staff) m.m.z.warowny@dundee.ac.uk; Mungo Carstairs (Staff) g.m.carstairs@dundee.ac.uk
Cc: Jalview Development List jalview-dev@jalview.org
Subject: Re: Matching protein / nucleotide services to alignments in Jalview

Mungo - do you feel the need to patch 2.11.1 to fix up its behaviour ?

(ps - cced jalview-dev…).

On 14/11/2019 13:24, Mateusz Warowny (Staff) wrote:

In Slivka each service has classifiers which helps to identify services and and can be used to determine input and output types:
e.g JRonn, Globblot are tagged “Protein sequence analysis”, msa e.g. Clustal, t_coffee are tagged “Sequence alignment :: Multiple sequence alignment”, aacon has “Sequence alignment analysis :: Sequence alignment analysis (conservation)” tag.

From: James Procter (Staff) J.Procter@dundee.ac.uk
Sent: 14 November 2019 13:21
To: Mungo Carstairs (Staff) g.m.carstairs@dundee.ac.uk; Mateusz Warowny (Student) m.m.warowny@dundee.ac.uk
Subject: Re: Matching protein / nucleotide services to alignments in Jalview

Actually covered by JAL-1172 - but is being addressed in the Slivka revamp of Jalview’s services in 2.12.

https://issues.jalview.org/browse/JAL-1172

j.

On 14/11/2019 13:16, Mungo Carstairs (Staff) wrote:

Is there, or could there be, a way to identify services (e.g. JRonn, GlobPlot etc) that are for protein alignments only, so that they could be disabled or hidden as menu options in Jalview (or other client) for a DNA or RNA alignment (and vice versa)?

Older versions of Jalview show a warning after requesting the service, e.g. “JRonnWS can only be used for amino acid alignments.”.
This warning was suppressed (2013 by Dan Barton) when RNAAlifold prediction was added (JAL-1358).

Jalview behaviour in 2.11 is mixed (up):

  • you can request disorder prediction for nucleotide but nothing happens, no error message appears
  • AbstractJabaCalcWorker.getInputSequences() returns null if nucleotide alignment but peptide service- you can request and get a JPred peptide secondary structure prediction for a nucleotide alignment
  • AACon service is disabled for nucleotide alignments
  • RNAAlifold is disabled for protein alignments
  • you can request a Multi-Harmony analysis for a partitioned nucleotide alignment (but it fails)

Mungo

Email signature

University of
                          Dundee shield logo

Mungo Carstairs
Jalview Computational Scientist

The Barton Group
Division of Computational Biology

School of Life Sciences

University of Dundee, Dundee, Scotland, UK

www.jalview.org

www.compbio.dundee.ac.uk
g.m.carstairs@dundee.ac.uk

University of
                            Dundee FacebookUniversity of Dundee TwitterUniversity of
                            Dundee LinkedInUniversity of
                            Dundee YouTubeUniversity of
                            Dundee InstagramUniversity of
                            Dundee Snapchat
We’re Scottish University of the Year again!
The Times / Sunday Times Good University Guide 2016 and 2017

-- 
-------------------------------------------------------------------
Dr JB Procter, Jalview Coordinator, The Barton Group
Division of Computational Biology, School of Life Sciences
University of Dundee, Dundee DD1 5EH, UK.
+44 1382 388734 | [www.jalview.org](http://www.jalview.org) | [www.compbio.dundee.ac.uk](http://www.compbio.dundee.ac.uk)

-- 
-------------------------------------------------------------------
Dr JB Procter, Jalview Coordinator, The Barton Group
Division of Computational Biology, School of Life Sciences
University of Dundee, Dundee DD1 5EH, UK.
+44 1382 388734 | [www.jalview.org](http://www.jalview.org) | [www.compbio.dundee.ac.uk](http://www.compbio.dundee.ac.uk)

The University of Dundee is a registered Scottish Charity, No: SC015096