Mapping genomic sequence variants on to protein structure

The latest video on our Jalview YouTube channel is a walkthrough video by Dr David Martin. David demonstrates Jalview’s new split frame window that links coding DNA sequences in the exons with protein sequences and structure.

David shows how Jalview can propagate variant annotation on genomic regions onto transcripts and protein products. Thus it is now possible to use Jalview’s multiple window desktop to view genomic sequence variants (from Ensembl), and directly link these to their protein sequences (from Uniprot), and then map these onto their 3D structure (from PDB).

The split frame window is available in the 2.10.0 version of Jalview. This can be launched by clicking the pink ‘Launch Jalview Desktop’ button on the Jalview home page.